_1704003999 20231231062639000 Rovedar Daryoushbabazadeh@gmail.com Rovedar Journal of Lab Animal Research J Lab Anim. Res 2980-9703 12 25 2023 2 6 Ghasem Dolatkhah Laein https://orcid.org/0009-0003-7325-8029 Samin Safarian https://orcid.org/0009-0001-0980-9055 Saba Delasaeimarvi https://orcid.org/0009-0006-4462-2743 Ghazale Sadat Ahmadi https://orcid.org/0000-0002-7480-2589 Sima Dadfar https://orcid.org/0009-0002-4020-8554 Elahe Bakhshi https://orcid.org/0009-0001-1919-7937 Amir Reza Rashidzade https://orcid.org/0009-0004-4941-2679 Introduction: Cancer is one of the most prevalent and complex diseases with diverse etiology and manifestations. Curcumin is a bioactive compound found in turmeric and could have therapeutic potential for cancer due to its antitumor properties. Curcumin's properties in treating various types of cancer have been reviewed in this systematic review based on in vivo studies. Materials and methods: This systematic review focused on in vivo studies examining Curcumin's anti-cancer properties across a broad range of cancer types. PubMed, Google Scholar, and Scopus databases were searched to identify relevant articles. Researchers selected studies evaluating Curcumin's effects on cancer progression and development based on animal models. Final analyses were conducted on the data obtained from the selected articles. The included studies were published between 2000 and 2023. Results: The current systematic review was based on 53 articles out of 412 eligible studies, which were selected from 770 articles of literature screened from 2000 to 2023. Based on this review, in vivo studies have demonstrated that curcumin can potentially treat various cancers. There is evidence that curcumin has significant anti-cancer properties, including tumor growth inhibition, metastasis inhibitory activity, and angiogenesis. 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