_1698904922 20231102060202000 Rovedar Daryoushbabazadeh@gmail.com Rovedar Journal of Lab Animal Research J Lab Anim. Res 2980-9703 10 25 2023 2 5 Ahmad Mir Hosseini https://orcid.org/0009-0006-8425-4463 Mohammad Amin Salim https://orcid.org/0009-0006-1409-5663 Parisa Pourfaraziani https://orcid.org/0009-0001-5486-3026 Mohadeseh Jamali https://orcid.org/0009-0007-1453-7641 Negar Agahi https://orcid.org/0009-0007-3920-0885 Alireza Azizi Mahsa Mohammadian https://orcid.org/0009-0001-1130-323X Approximately, 1 to 2% of the population in developed countries suffer from chronic wounds. Nearly 6.5 million Americans have suffered at least one chronic wound. Chronic wound treatment is critical for patients to maintain their mental and physical well-being and improve their life quality. Chronic wounds can be treated in various ways, including hyperbaric oxygen therapy, debridement, ultrasound, skin grafts, negative pressure wound therapy, electromagnetic therapies, and hydrogel dressings. Hydrogels are among the most viable and promising options since their tunable characteristics, such as adhesiveness, antimicrobial and biodegradability, pre-angiogenic bioactivities, and anti-inflammatory, are beneficial to healing chronic wounds. In in vivo studies utilizing animal models, hydrogel dressings emerged as multifunctional solutions for chronic wound healing. These investigations consistently demonstrated that hydrogel dressings accelerated wound healing rates compared to traditional methods and maintained an optimal moist wound environment, which fostered tissue regeneration while minimizing scarring. Moreover, the remarkable biocompatibility of hydrogel dressings became evident in these animal model experiments, as they showed minimal adverse reactions in chronic wound patients. The results of these in vivo studies collectively highlight the promising potential of hydrogel dressings as a versatile therapeutic option for effectively managing chronic wounds. This review discusses dressings made of hydrogel in animal models for their multifunctional properties and potential benefits in treating chronic wounds. The efficacy of hydrogel dressings over other kinds of dressings is also demonstrated by providing examples of commercially available hydrogel dressings. 10 25 2023 41 50 https://creativecommons.org/licenses/by/4.0 10.58803/jlar.v2i5.28 https://jlar.rovedar.com/index.php/JLAR/article/view/28 https://jlar.rovedar.com/index.php/JLAR/article/download/28/55 https://jlar.rovedar.com/index.php/JLAR/article/download/28/55 10.1038/s41572-020-0145-5 10.1002/advs.202105152 10.1038/s41572-022-00377-3 10.1016/j.jconrel.2020.09.039 10.2337/dci22-0043 10.1038/s41374-021-00675-6 10.1111/iwj.12557 10.1016/j.clindermatol.2006.12.005 10.3390/ijms17122085 10.1002/adfm.201304202 10.1021/acsami.1c23461 10.1016/j.ijbiomac.2023.126010 10.1016/j.actbio.2022.05.047 10.1021/acsami.2c08593 10.1002/mabi.202100475 10.55544/jrasb.1.4.10 10.1016/j.mpmed.2013.04.017 10.1016/j.mpmed.2017.03.004 10.1016/j.fsc.2017.03.001 Kanitakis J. Anatomy, histology and immunohistochemistry of normal human skin. European journal of dermatology. 2002;12(4):390-401. 10.1016/j.mpsur.2007.11.005 10.1007/s42765-022-00178-z 10.1038/s41570-021-00323-z 10.1016/j.ijbiomac.2021.10.013 10.1002/ctm2.1094 10.3390/ijms22020897 10.3390/cells11152430 10.4103/1947-2714.103342 10.1111/iwj.13713 10.1002/adma.202100176 10.1002/adhm.201801210 10.1002/cbf.3424 10.1016/j.smaim.2022.08.001 10.1016/j.cej.2021.133091 10.3390/pharmaceutics12080735 10.1097/01.ASW.0000416006.55218.d0 10.1002/app.47738 10.1002/adhm.201901502 10.1002/jps.21210 10.1016/j.jaad.2011.06.028 10.7603/s40681-015-0022-9 10.1016/j.ijbiomac.2022.12.116 10.1021/acsnano.1c04206 10.1016/B978-0-08-102192-7.00002-3 10.2174/1389201023378283 Toppo FA, Pawar RS. Novel drug delivery strategies and approaches for wound healing management. J Crit Rev. 2015;2(2):12À20. 10.1016/j.reactfunctpolym.2021.105059 10.1039/D3TB00639E 10.1039/D1QM00561H 10.3923/pjbs.2013.1438.1448 Obagi Z, Damiani G, Grada A, Falanga V. Principles of wound dressings: a review. Surg Technol Int. 2019;35:50-7. 10.1016/j.injury.2013.12.005 10.1111/dth.12055 10.2147/CWCMR.S50832 10.2217/cer-2020-0268 Atkin L, Stephenson J, Bateman S. Foam dressings: a review of the literature and evaluation of the fluid-handling capacity of four leading foam dressings. Wounds UK. 2015;11(1):75-81. 10.1002/pat.5929 10.3390/ijerph17217881 10.2147/CWCMR.S260136 10.3390/gels8020127 10.1002/adhm.202201021 10.1016/j.msec.2019.110040 10.3389/fbioe.2022.825339 10.1016/j.jconrel.2023.01.049 10.1016/j.biomaterials.2022.121597 10.3390/molecules28020604 10.1016/j.seppur.2021.118731 10.1016/j.biomaterials.2011.05.078 10.1002/app.42458 10.1002/pat.5661 10.1039/D0BM00055H 10.18063/ijb.759 10.1007/s10853-015-9382-5 10.1016/j.bioactmat.2022.04.020 10.1002/anbr.202100004 10.1002/pol.20210916 10.1016/j.cej.2021.130843 10.3390/gels9030185 10.3390/pharmaceutics13070981 10.1016/j.eurpolymj.2021.110268 10.1002/mabi.202000252 10.53350/pjmhs20231732 10.3390/gels8020070 10.1016/j.ijbiomac.2022.01.193 10.4012/dmj.2016-301 10.1002/advs.201700527 10.3390/nano8060359 10.1007/s40820-021-00751-y 10.1016/j.ijantimicag.2012.04.012 10.1002/mabi.202300094 10.1016/j.msec.2020.111596 10.3389/fbioe.2021.650598 10.1016/j.ijbiomac.2022.10.055 10.1016/j.carbpol.2022.119467 10.1007/s00018-016-2268-0 10.1039/D1BM01211H 10.1016/j.ijbiomac.2020.03.207 10.1016/j.addr.2018.04.008 10.1038/natrevmats.2016.71 10.1016/j.matdes.2021.110104 10.3390/polym14142764