_1689488577 20230716062257000 Rovedar Daryoushbabazadeh@gmail.com Rovedar Journal of Lab Animal Research J Lab Anim. Res 2980-9703 06 25 2023 2 3 Mir Asadollah Amiri Nona Moradpour https://orcid.org/0009-0003-6749-5722 Hassan Borji Introduction: Rodents are the largest group of mammals and act as a reservoir for many common human diseases, leading to societal health and economic problems. Due to the different prevalence rates of rodent-borne parasitic infections in various regions, this study was conducted to determine the prevalence of intestinal parasites in wild and domestic rodents in Kalat County, located in the north of Khorasan Razavi Province, Iran, in 2016. Materials and methods: The study was performed using a descriptive method on 86 mountainous and domestic rodents randomly caught using live traps. After anesthesia and species identification, the gastrointestinal tract was dissected, and the digestive system worms were separated and preserved in 10% formalin until identification. The nematodes were clarified with lactophenol and stained with carmine acid. All worms were identified using diagnostic keys, and the results were presented using descriptive statistics. Results: The prevalence of gastrointestinal worm infections in rodents in the study area was 75.5%. The captured rodents in this area included Microtus 46 (53.4%), Mus musculus 15 (17.4%), Pikas 13 (15.1%), Apodemus agrarius 11 (12.7%), and Allactaga elater 1 (1.1%). Six species of nematodes and one cestode species were identified in this study. The prevalence of parasitic infections shared between humans and rodents included Syphacia obvelata (83%), Aspicularis tetraptera (18.5%), Trichuris fossor (16.9%), Hymenolepis nana (6.1%), Heligmosomoides polygyrus (10.7%), and Nipostrongylus braziliensis (1.5%). Capillaria spp were found in 1.5% of rodents. Conclusion: The results revealed a high prevalence of gastrointestinal worm infections in rodents, with an overall prevalence rate of 75.5% in Kalat, Iran. These findings highlight the potential health risks associated with rodent-borne parasitic infections in the study area and emphasize the importance of implementing effective control and prevention measures to mitigate the impact on human health and the local economy. 06 25 2023 11 15 https://creativecommons.org/licenses/by/4.0 10.58803/jlar.v2i3.18 https://jlar.rovedar.com/index.php/JLAR/article/view/18 https://jlar.rovedar.com/index.php/JLAR/article/download/18/43 https://jlar.rovedar.com/index.php/JLAR/article/download/18/43 10.1038/s41598-020-69998-6 10.1093/jmammal/gyy179 10.1007/s11252-022-01292-x 10.1007/978-981-15-8075-8_11 ShahrokhiA, MoradpourN, SiahsarvieR, and BorjiH. An investigation of potentially zoonotic helminth parasites of allactaga elaterin Sarakhs, Iran. J Lab Anim Res. 2022; 1(1): 8-13. Available at: https://jlar.rovedar.com/index.php/JLAR/article/view/7/14 10.1080/20008686.2018.1553461 10.1016/j.onehlt.2021.100364 10.3390/microorganisms8091405 10.1007/s00726-020-02823-6 10.58803/fahn.v1i2.10 10.54203/scil.2023.wvj7 Sadr S, Charbgoo A, Borji H, and Hajjafari A. Interactions between innate immunity system and Echinococcus granulosus: Permission for vaccine development. Series Med Sci. 2022; 3(1): 1-18. Available at: https://seriesscience.com/wp-content/uploads/2023/01/Interactions-between-Innate-Immunity.pdf 10.1007/s11686-023-00680-3 10.23937/2643-4512/1710039 10.3390/ani10101916 10.1016/j.eclinm.2021.101054 10.1017/S0022149X23000020 10.1016/j.parepi.2022.e00245 10.1016/j.onehlt.2023.100517 Shahabi S, Pouryousef A, Azizi K, and Sarkari B. Intestinal helminths infections of calomyscus cf. bailwardi (Rodentia: Calomyscidae) from Fars Province, Southern Iran. J Health Sci Surveill Syst. 2019; 7(3): 163-166. DOI: 10.30476/jhsss.2020.85071.1054 10.20473/jmv.vol5.iss2.2022.196-206 10.1089/vbz.2005.5.305 10.1080/10408410902989837 10.1371/journal.pntd.0006256 10.1111/1749-4877.12143 10.1016/j.cimid.2020.101580 Julius RS, Zengeya TA, Schwan EV, and Chimimba CT. Geospatial modelling and univariate analysis of commensal rodent-borne cestodoses: The case of invasive spp. of Rattus and indigenous Mastomys coucha 10.3389/fvets.2021.678478 10.1007/s00580-018-2690-9 10.3389/fcimb.2021.639573 10.1111/mam.12201