eng Rovedar Publication Journal of Lab Animal Research 2022-12-25 1 1 41 46 22 Ashkan Hajjafari 0 https://orcid.org/0000-0003-2849-9125 Pouria Ahmadi Simab 1 https://orcid.org/0000-0003-1507-8815 Soheil Sadr 2 https://orcid.org/0000-0002-9068-0673 Narges Lotfalizadeh 2 https://orcid.org/0000-0003-4910-5498 Hassan Borji 3 https://orcid.org/0000-0003-4706-4995 Department of Pathobiology, Faculty of Veterinary Medicine, Islamic Azad University, Science and Research Branch, Tehran, Iran Department of Clinical Sciences, Faculty of Veterinary Medicine, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran Despite significant progress in the fight against cancer, cancer treatment remains a significant public health concern and a societal burden worldwide. To develop better intervention strategies to counter tumor development, it is important to understand the molecular and cellular mechanisms underlying oncogenic diseases. In-vivo and in-vitro models have traditionally been utilized to understand the biological processes involved in cancer, including apoptosis, proliferation, angiogenesis, invasion, metastasis, genome instability, and metabolism. The present review aims to look at the way Caenorhabditis elegans (C. elegans) can affect cancer cellular and molecular bases, concentrating on mechanisms like apoptosis and autophagy. In recent years, . elegans has emerged as a promising model organism for studying the molecular basis of tumorigenesis. This model organism is attractive since it is genetically tractable and has a simple and well-understood anatomy. The C. elegans exhibits conserved cellular pathways and mechanisms relevant to human diseases, including cancer. Furthermore, C. elegans has been used to study the roles of tumor suppressor genes and oncogenes in tumorigenesis. In conclusion, C. elegans is an emerging animal model that has the potential to facilitate the development of better intervention strategies to prevent or counter tumor development and to advance our understanding of cancer progression with further research. https://jlar.rovedar.com/index.php/JLAR/article/view/12 Apoptosis Autophagy Cancer Caenorhabditis elegans